To run Drupal, you will need the following infrastructure:
1. **Web Server**: Drupal runs on a server that supports PHP and MySQL, PostgreSQL, or SQLite databases. Popular web servers like Apache, Nginx, or Microsoft IIS can be used to run Drupal.
2. **PHP**: Drupal is a PHP application, so you'll need an installed and configured PHP interpreter on your server. It's recommended to use a PHP version supported by the current version of Drupal.